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PRMT5-IN-50

CAT: 0013-GTR19258327-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258327-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.
CAS Number
3002409-47-1
Field of Research
Epigenetics & Chromatin
Smiles
C (N (CC1=CC=C (C (F) (F) F) C=N1) [C@H] (C) C=2N=CC=CN2) (=O) C3=CC4=C (N=C (N) C (=C4) C5CC5) C=C3
Molecular Formula
C26H23F3N6O
Molecular Weight
492.496
Storage Conditions
-20°C
Notes
For research use only.

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