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Keap1-Nrf2-IN-28

CAT: 0804-HY-172598Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172598Size:1 Each
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Description
Keap1-Nrf2-IN-28 (SG16) is an orally active Keap1-Nrf2 inhibitor. Keap1-Nrf2-IN-28 shows antioxidant capability and induces the upregulation of Nrf2, HO-1, GCLM, and Akr1c1. Keap1-Nrf2-IN-28 attenuates APAP -induced acute liver injury[1].
CAS Number
3075750-60-3
UNSPSC
12352005
Target
Keap1-Nrf2
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=CC=C(F)C=C1)(NC2=CC3=C(C=C2)C(C=C(C4=CC=C(OC)C=C4)O3)=O)=O
Molecular Formula
C22H16FNO5S
Molecular Weight
425.43
References & Citations
[1]Sang Y, et al. Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo. Eur J Med Chem. 2025 Jul 5;291:117650.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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