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Antitumor agent-195

CAT: 0804-HY-170947Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170947Size:1 Each
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Description
Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model[1].
UNSPSC
12352005
Target
Quinone Reductase; STAT
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=C(C2=C3C4=C(C(N(CCN5CCCCC5)CC4)=O)O2)C=CC=C1)C3=O
Molecular Formula
C22H22N2O4
Molecular Weight
378.42
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NQO1; STAT3

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