Antitumor agent-195

CAT: 0931-T205391-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205391-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Reductase, STAT

Related Pathways

JAK/STAT signaling, Endocrinology/Hormones, Stem Cells, Metabolism

Bioactivity

Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.

Molecular Formula

C22H22N2O4

Molecular Weight

378.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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