CM-118

• Description:

  CM-118 is a potent and selective c-Met and ALK inhibitor. CM-118 inhibits the HGF-induced c-Met phosphorylation. CM-118 inhibits phosphorylation of ALK, EML4-ALKv1, ALK F1174L, and EMl4-ALKv1 L1196M, with respective IC50 values 0.92, 1.25, 1.9, and 3.5 μM. CM-118 exhibits anticancer activity against cancers dependent on the c-Met or ALK oncogenic pathways[1].

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  C[C@H] (C1=C (C (F) =CC=C1Cl) Cl) OC2=C (N) N=NC (C (NC3=CN (C (C=C3) =O) C) =O) =C2

• Molecular Formula:

  C19H16Cl2FN5O3

• Molecular Weight:

  452.27

• References & Citations:

  [1]Meng L, et al. A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers. Cancer Biol Ther. 2014 Jun 1;15 (6) :721-34.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1370652-56-4