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CM-118

CAT: 0804-HY-165284Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-165284Size:1 Each
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Description
CM-118 is a potent and selective c-Met and ALK inhibitor. CM-118 inhibits the HGF-induced c-Met phosphorylation. CM-118 inhibits phosphorylation of ALK, EML4-ALKv1, ALK F1174L, and EMl4-ALKv1 L1196M, with respective IC50 values 0.92, 1.25, 1.9, and 3.5 μM. CM-118 exhibits anticancer activity against cancers dependent on the c-Met or ALK oncogenic pathways[1].
CAS Number
1370652-56-4
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C[C@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=C(N)N=NC(C(NC3=CN(C(C=C3)=O)C)=O)=C2
Molecular Formula
C19H16Cl2FN5O3
Molecular Weight
452.27
References & Citations
[1]Meng L, et al. A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers. Cancer Biol Ther. 2014 Jun 1;15 (6) :721-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-(1-methyl-6-oxo-3-pyridinyl)pyridazine-3-carboxamide
CAS Number1370652-56-4
PubChem CID56951325
IUPAC Name6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-(1-methyl-6-oxo-3-pyridinyl)pyridazine-3-carboxamide
Molecular FormulaC19H16Cl2FN5O3
Molecular Weight452.3
XLogP2.1
Topological Polar Surface Area110
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity724
SMILES
C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CN(C(=O)C=C3)C
InChI
InChI=1S/C19H16Cl2FN5O3/c1-9(16-11(20)4-5-12(22)17(16)21)30-14-7-13(25-26-18(14)23)19(29)24-10-3-6-15(28)27(2)8-10/h3-9H,1-2H3,(H2,23,26)(H,24,29)/t9-/m1/s1
InChIKey
CAHIYUNFMZWRQZ-SECBINFHSA-N
Chemical Structure
2D Structure
2D structure of 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-(1-methyl-6-oxo-3-pyridinyl)pyridazine-3-carboxamide
CAS: 1370652-56-4
CID: 56951325
Formula: C19H16Cl2FN5O3
MW: 452.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight452.3
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass451.0614229
Monoisotopic Mass451.0614229
Topological Polar Surface Area110 Ų
Heavy Atom Count30
Formal Charge0
Complexity724
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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