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LQB-118

CAT: 0804-HY-124068Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124068Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases[1][2][3][4].
CAS Number
1219104-20-7
UNSPSC
12352005
Target
Apoptosis; GSK-3; MMP; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lqb-118.html
Smiles
O=C1C2=C(C(C3=CC=CC=C31)=O)OC[C@@]4([H])[C@]2([H])OC5=CC=CC=C45
Molecular Formula
C19H12O4
Molecular Weight
304.30
References & Citations
[1] Bernardo PS, et al. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020 Jan;43 (1) :346-357. |[2]Martino T, et al. LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression. Anticancer Res. 2023 Jan;43 (1) :359-367. |[3]Lima ÉA, et al. The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro. Int Immunopharmacol. 2020 Jun;83:106399. |[4]Ribeiro GA, et al. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Apr;68 (4) :789-99.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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