CM-444

• Description:

  CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM) . CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1].

• UNSPSC:

  12352005

• Target:

  DNA Methyltransferase; HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cm-444.html

• Smiles:

  O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO

• Molecular Formula:

  C27H30N6O5

• Molecular Weight:

  518.56

• References & Citations:

  [1]San José-Enériz E, et al., Epigenetic-based differentiation therapy for Acute Myeloid Leukemia. Nat Commun. 2024 Jul 2;15 (1) :5570.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DNMT1; DNMT3; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9