Products for Research Use Only
RegisterLogin

CM-444

CAT: 0804-HY-163803Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-163803Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM) . CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1].
UNSPSC
12352005
Target
DNA Methyltransferase; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cm-444.html
Smiles
O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO
Molecular Formula
C27H30N6O5
Molecular Weight
518.56
References & Citations
[1]San José-Enériz E, et al., Epigenetic-based differentiation therapy for Acute Myeloid Leukemia. Nat Commun. 2024 Jul 2;15 (1) :5570.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT1; DNMT3; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9

Related Products

CatalogName
HY-125602MNI-444
HY-142870-01ZY-444
HY-100685-01MS-444
HY-W953748CRBN ligand-444
HY-B2221C-01CM Cellulose CM-32
HY-P990569-01CM-24
HY-121516-01CM-TPMF
HY-114303-01CM-675
HY-170488CM-728
HY-165284CM-118

Alternative Products

CatalogName
T210199-01CM-444
AGA04518-01MS-444
T33461MNI-444
T62620-01ZY-444
T7183-01CPI-444

Popular Products