LQB-118

• Target:

  Apoptosis|||Reactive Oxygen Species|||MMP|||GSK-3

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||Apoptosis|||Proteases/Proteasome|||Stem Cells|||PI3K/Akt/mTOR signaling|||NF-?B

• Bioactivity:

  LQB-118, an orally active compound sourced from sandalwood, demonstrates multiple therapeutic capabilities. It has shown proficiency in inhibiting glioblastoma cell migration and inducing apoptosis. Additionally, LQB-118 can curtail both migration and invasion of prostate cancer cells by modulating the AKT/GSK3? pathway and regulating MMP-9/reck gene expression. The compound is also effective against yeast polysaccharide-induced inflammation in both in vivo and in vitro settings. Notably, LQB-118 specifically triggers ROS-mediated and mitochondrial-dependent apoptosis in Leishmania amazonensis, highlighting its potential in studies focusing on inflammation, infections, and various cancers.

• Smiles:

  O=C1C=2[C@@]3([C@@](C=4C(O3)=CC=CC4)(COC2C(=O)C=5C1=CC=CC5)[H])[H]

• Molecular Formula:

  C19H12O4

• Molecular Weight:

  304.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1219104-20-7