RTI-118

CAT: 0804-HY-111308-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-111308-01Size:5 mg

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Description

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration[1].

CAS Number

847554-50-1

UNSPSC

12352005

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rti-118.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCCN5CCCCC5

Molecular Formula

C26H32N4O3

Molecular Weight

448.56

References & Citations

[1]Schmoutz CD, et al.Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats.Pharmacol Biochem Behav. 2012 Dec;103 (2) :332-7.|[2]Bonano JS, et al. Effects of the neuropeptide S receptor antagonist RTI-118

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

3-oxo-1,1-di(phenyl)-N-(2-piperidin-1-ylethyl)-5,6,8,8a-tetrahydro-[1,3]oxazolo[4,3-c]pyrazine-7-carboxamide

CAS Number	847554-50-1
PubChem CID	23121947
IUPAC Name	3-oxo-1,1-diphenyl-N-(2-piperidin-1-ylethyl)-5,6,8,8a-tetrahydro-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide
Molecular Formula	C26H32N4O3
Molecular Weight	448.6
XLogP	3
Topological Polar Surface Area	65.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Heavy Atom Count	33
Formal Charge	0
Complexity	665

SMILES

C1CCN(CC1)CCNC(=O)N2CCN3C(C2)C(OC3=O)(C4=CC=CC=C4)C5=CC=CC=C5

InChI

InChI=1S/C26H32N4O3/c31-24(27-14-17-28-15-8-3-9-16-28)29-18-19-30-23(20-29)26(33-25(30)32,21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-2,4-7,10-13,23H,3,8-9,14-20H2,(H,27,31)

InChIKey

JJDDRYMIPIEXKX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 847554-50-1

CID: 23121947

Formula: C26H32N4O3

MW: 448.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	448.6
XLogP3	3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	448.24744090
Monoisotopic Mass	448.24744090
Topological Polar Surface Area	65.1 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	665
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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