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EUK-118

CAT: 0804-HY-130438Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130438Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EUK-118 is an analog of EUK 8 and EUK 134 with reduced activity. EUK-118 exhibits superoxide dismutase (SOD) mimetic activity[1][2].
CAS Number
186299-34-3
UNSPSC
12352300
Target
SOD
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/euk-118.html
Solubility
10 mM in DMSO
Smiles
CC([O-][Mn+3]123[N](CC[N]2=CC4=C(OC)C=C(OC)C=C4[O-]3)=CC5=C(C=C(OC)C=C5OC)[O-]1)=O
Molecular Formula
C22H25MnN2O8
Molecular Weight
500.38
References & Citations
[1]Doctrow SR, et, al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J Med Chem. 2002 Sep 26;45 (20) :4549-58.|[2]Vera M, et, al. Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease. Cell Physiol Biochem. 2018;51 (3) :1287-1300.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

CID 53394082
CAS Number186299-34-3
PubChem CID53394082
IUPAC Name2-[2-[(2,4-dimethoxy-6-oxidophenyl)methylideneamino]ethyliminomethyl]-3,5-dimethoxyphenolate;manganese;acetate
Molecular FormulaC22H25Mn3N2O8-3
Molecular Weight610.3
Topological Polar Surface Area148
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge-3
Complexity559
SMILES
CC(=O)[O-].COC1=CC(=C(C(=C1)OC)C=NCCN=CC2=C(C=C(C=C2OC)OC)[O-])[O-].[Mn].[Mn].[Mn]
InChI
InChI=1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;1-2(3)4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4);;;/p-3
InChIKey
MAFGPDWFRWXFGZ-UHFFFAOYSA-K
Chemical Structure
2D Structure
2D structure of CID 53394082
CAS: 186299-34-3
CID: 53394082
Formula: C22H25Mn3N2O8-3
MW: 610.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight610.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass609.975220
Monoisotopic Mass609.975220
Topological Polar Surface Area148 Ų
Heavy Atom Count35
Formal Charge-3
Complexity559
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count5
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
C4669-50EUK 118
2173-5EUK-118
DCA17712-01EUK-8
2175-5EUK-134
2174-25EUK-124
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