NK7-902 TFA

• Target:

  Molecular Glues|||MAPK

• Related Pathways:

  PROTAC|||MAPK

• Bioactivity:

  NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1? production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C