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F9170 TFA

CAT: 0931-T83707-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T83707-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
HIV Protease
Related Pathways
Microbiology/Virology|||Proteases/Proteasome
Bioactivity
F9170, an antiviral peptide derived from the HIV-1 envelope glycoprotein (amino acids 789-803), targets the LLP1 domain in the virus's envelope protein cytoplasmic tail. This interaction inhibits HIV-1 IIIB infection in MT-2 cells, evidenced by an EC50 value of 0.19 µM. Additionally, at a dosage of 3 mg/kg, F9170 significantly lowers plasma viral load in rhesus macaques infected with simian HIV (SHIV) .
Smiles
OC(C(F)(F)F)=O.OC(C=C1)=CC=C1C[C@H](NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@@H](NC(CN)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(O)=O)CC4=CNC5=CC=CC=C45)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O
Molecular Formula
C100H135N21O22.XCF3COOH
Molecular Weight
1983.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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HY-P10310F9170
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