NK7-902

• Target:

  MAPK

• Related Pathways:

  MAPK

• Bioactivity:

  NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1? production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C