NK7-902 (TFA)

• Description :

  NK7-902 TFA is a CRBN molecular glue degrader of NEK7. NK7-902 TFA fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 TFA leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 TFA shows activity in murine systems[1].

• UNSPSC :

  12352005

• Target :

  Molecular Glues; NEKs

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Field of Research :

  Inflammation/Immunology

• Purity :

  98.86

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCN[C@@H]1CC[C@@H]2N(C3=CC=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=C3)[C@H]1CC2.OC(C(F)(F)F)=O

• Molecular Formula :

  C24H27F3N4O6

• Molecular Weight :

  524.49

• References & Citations :

  [1]Sylvain A, et, al. A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation. bioRxiv. 2024.11.06.622079.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported