NK7-902 (diTFA)

• Description:

  NK7-902 diTFA is an orally active CRBN molecular glue degrader of NEK7. NK7-902 diTFA fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 diTFA leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 diTFA shows activity in murine systems[1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues; NEKs

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Purity:

  98.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCN[C@@H]1CC[C@@H]2N(C3=CC=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=C3)[C@H]1CC2.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

• Molecular Formula:

  C26H28F6N4O8

• Molecular Weight:

  638.51

• References & Citations:

  [1]Sylvain A, et, al. A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation. bioRxiv. 2024.11.06.622079.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported