TC-2559 free base

CAT: 0931-T211478-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211478-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

189274-78-0

Target

STAT, AChR

Related Pathways

Stem Cells, JAK/STAT signaling, Neuroscience

Bioactivity

TC-2559 free base is an α4β2 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 0.18 μM. It shows weaker agonistic effects on β4 subunit nAChR genotypes (α2β4, α4β4, and α3β4 receptors), with EC50 values ranging from 10-30 μM. In vitro, TC-2559 free base enhances dopamine cell firing in the rat ventral tegmental area (VTA), increasing the excitability and bursting activity of VTA dopaminergic neurons. It also inhibits STAT3 to exert anti-inflammatory effects, alleviates mechanical allodynia in mice, and improves cognitive deficits in rats. TC-2559 free base is utilized in neuropathic pain research.

Smiles

C(=C/CCNC)\C=1C=C(OCC)C=NC1

Molecular Formula

C12H18N2O

Molecular Weight

206.28

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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