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TC-2559 free base

CAT: 0013-GTR19263859-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263859-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TC-2559 free base is an α4β2 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 0.18 μM. It shows weaker agonistic effects on β4 subunit nAChR genotypes (α2β4, α4β4, and α3β4 receptors), with EC50 values ranging from 10-30 μM. In vitro, TC-2559 free base enhances dopamine cell firing in the rat ventral tegmental area (VTA), increasing the excitability and bursting activity of VTA dopaminergic neurons. It also inhibits STAT3 to exert anti-inflammatory effects, alleviates mechanical allodynia in mice, and improves cognitive deficits in rats. TC-2559 free base is utilized in neuropathic pain research.
CAS Number
189274-78-0
Field of Research
Neuroscience, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C (=C/CCNC) \C=1C=C (OCC) C=NC1
Molecular Formula
C12H18N2O
Molecular Weight
206.28
Storage Conditions
-20°C
Notes
For research use only.

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