Netarsudil free base

CAT: 0931-MF-0145381-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145381-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1254032-66-0
Target
Others|||Monoamine Transporter|||ROCK
Related Pathways
Membrane transporter/Ion channel|||Cytoskeletal Signaling|||Stem Cells|||Others|||Cell Cycle/Checkpoint
Bioactivity
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1?nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16?nM, respectively, and blocked the profibrotic effects of TGF-?2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24?h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.
Smiles
N(C([C@H](CN)C1=CC=C(COC(=O)C2=C(C)C=C(C)C=C2)C=C1)=O)C3=CC4=C(C=C3)C=NC=C4
Molecular Formula
C28H27N3O3
Molecular Weight
453.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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