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Netarsudil free base

CAT: 0931-T71119-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71119-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1254032-66-0
Target
Others, Monoamine Transporter, ROCK
Related Pathways
Membrane transporter/Ion channel, Cytoskeletal Signaling, Stem Cells, Others, Cell Cycle/Checkpoint
Bioactivity
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.
Smiles
N(C([C@H](CN)C1=CC=C(COC(=O)C2=C(C)C=C(C)C=C2)C=C1)=O)C3=CC4=C(C=C3)C=NC=C4
Molecular Formula
C28H27N3O3
Molecular Weight
453.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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