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PBT434 (free base)

CAT: 0804-HY-120475BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120475BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc) . PBT434 free base has the potential for the research of Parkinson’s disease (PD) [1][2].
CAS Number
1232840-87-7
Product Name Alternative
ATH434 (free base)
UNSPSC
12352005
Target
α-synuclein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O
Molecular Formula
C12H13Cl2N3O2
Molecular Weight
302.16
References & Citations
[1]Bailey DK, et al. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16 (7) :e0254794.|[2]Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5 (1) :53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

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