SST0116CL1 (free base)

• Description :

  SST0116CL1 free base is a HSP90 inhibitor (IC50: 0.21 μM) . SST0116CL1 free base binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM) . SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma[1].

• UNSPSC :

  12352005

• Target :

  Akt; CDK; ERK; HSP

• Related Pathways :

  Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O

• Molecular Formula :

  C22H30N4O6

• Molecular Weight :

  446.50

• References & Citations :

  [1]Vesci L, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor. Int J Oncol. 2014 Oct;45 (4) :1421-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90

• CAS Number :

  [1202920-93-1]