Products for Research Use Only
RegisterLogin

SST0116CL1 (free base)

CAT: 0804-HY-164399ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-164399ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SST0116CL1 free base is a HSP90 inhibitor (IC50: 0.21 μM) . SST0116CL1 free base binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM) . SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma[1].
CAS Number
1202920-93-1
UNSPSC
12352005
Target
Akt; CDK; ERK; HSP
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O
Molecular Formula
C22H30N4O6
Molecular Weight
446.50
References & Citations
[1]Vesci L, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor. Int J Oncol. 2014 Oct;45 (4) :1421-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

Related Products

CatalogName
HY-164399SST0116CL1
HY-109118Masupirdine (free base)
HY-152852-01Mefatinib (free base)
HY-19651-01Zanapezil (free base)
HY-116031ATC0175 (free base)
HY-120421SW116 (free base)
HY-139806SRA880 (free base)
HY-100444-01SIS3 (free base)
HY-116565A-01Usmarapride (free base)
HY-125741-01GW768505A (free base)

Alternative Products

CatalogName
TB0954TMB free base
A8893-10Rucaparib (free base)
MBS5779607Amidantel free base
FX56092-01Xylazine - free base
XN175452-01Norharman - free base
T-8100-01Tryptamine, free base
T70071-01SLM6031434 (free base)
T11948-01Masupirdine free base
T71532-01Fondaparinux free base
T71268-01Esoxybutynin Free Base

Popular Products