Enadoline (Free Base)

• Target:

  Opioid Receptor|||Others

• Related Pathways:

  Neuroscience|||Endocrinology/Hormones|||GPCR/G Protein|||Others

• Bioactivity:

  Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S, S (-) -enantiomer; PD 129289 (CAM 569) is the corresponding R, R (+) -enantiomer. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a ?-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.

• Smiles:

  N(C(CC1=C2C(OC=C2)=CC=C1)=O)(C)C3C(CC4(CC3)CCCO4)N5CCCC5

• Molecular Formula:

  C24H32N2O3

• Molecular Weight:

  396.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  107431-28-7