NF-κB degrader 1

CAT: 0931-T210896-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210896-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

NF-κB

Related Pathways

NF-κB

Bioactivity

NF-κBdegrader 1 (Compound MD-1) is an NF-κB1p105 subunit degrader. It exhibits anti-inflammatory properties, with an IC50 of 2.02 μM for inhibiting TNF-α and 5.40 μM for inhibiting NO. NF-κBdegrader 1 induces p105 degradation via the Cullin-RING ligase (CRL) SCFBTCP, thereby inhibiting NF-κB transcriptional activity. This compound shows potential for research in inflammation-related diseases.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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NF-κB degrader 1

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