NF-κB degrader 1

CAT: 0804-HY-174138-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-174138-01Size:5 mg

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Description

NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM) . NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases[1].

UNSPSC

12352005

Target

NF-κB

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.92

Smiles

O=C1OC2=C(C=C(C=C2C=C1C3=CC=CC=C3)OC)C(/C=C(C)\C)=O

Molecular Formula

C21H18O4

Molecular Weight

334.37

References & Citations

[1]Choo MZY, et al. Discovery of an NF-κB1 p105 Degrader for Anti-Inflammatory Therapy via Structural Optimization of the Coumarin Natural Product Minutuminolate. J Med Chem. 2025 Jun 12;68 (11) :11081-11099.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NF-κB1/p50

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