STAT3/NF-κB-IN-1

CAT: 0931-T211396-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211396-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

STAT, Bcl-2 Family, NF-κB, Caspase, Apoptosis

Related Pathways

Proteases/Proteasome, JAK/STAT signaling, Apoptosis, NF-κB, Stem Cells

Bioactivity

STAT3/NF-κB-IN-1 is a potent inhibitor of STAT3 and NF-κB, exhibiting IC50 values of 5.86 μM for STAT3 and 4.22 μM for NF-κB in 4 T1 cells. It induces apoptosis by upregulating key apoptotic regulators (caspases-3, 9, Bax) and downregulating Bcl-2 expression. STAT3/NF-κB-IN-1 shows significant anticancer activity against breast cancer cell lines and can reduce tumor volume in vivo. It is applicable for research in breast cancer.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-175227	STAT3/NF-κB-IN-1
BA8604-1	NF-κB-IN-1
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GTR19185557-01	NF-κB/PON1-IN-1
HY-174138-01	NF-κB degrader 1
BUP05080-01	NF-?B/MAPK-IN-1
GTR19185546-01	NF-κB/MAPK-IN-1
HY-168710-01	TLR4/NF-κB-IN-1
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STAT3/NF-κB-IN-1

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