Nrf2 activator-10

• UNSPSC Description:

  Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.

• Target Antigen:

  Apoptosis; Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-10.html

• Smiles:

  O=C(C1=C(Cl)C2=C(C=CC=C2)N(C)C1=O)OCC

• Molecular Weight:

  265.69

• References & Citations:

  [1]Hur W, et al., A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28;17(5):537-47.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  75483-04-4