Nrf2 activator-10

Nrf2 activator-10

• CAS Number: 75483-04-4
• UNSPSC Description: Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
• Target Antigen: Apoptosis; Keap1-Nrf2
• Type: Reference compound
• Related Pathways: Apoptosis;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nrf2-activator-10.html
• Smiles: O=C(C1=C(Cl)C2=C(C=CC=C2)N(C)C1=O)OCC
• Molecular Weight: 265.69
• References & Citations: [1]Hur W, et al., A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28;17(5):537-47.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported