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RTx-161

CAT: 0931-T209721-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T209721-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, DNA/RNA Synthesis
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Bioactivity
RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. It selectively kills HR-deficient cancer cells and inhibits PARP inhibitor (PARPi) resistance across various genetic backgrounds, including HR-proficient cells. RTx-161 also induces apoptosis.
Molecular Formula
C21H18F7N3O4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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