KIM-161

• Target :

  PI3K|||Reactive Oxygen Species|||Akt|||Apoptosis|||mTOR

• Related Pathways :

  NF-?B|||Immunology/Inflammation|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling|||Apoptosis|||Metabolism

• Bioactivity :

  KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 µM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.

• Smiles :

  O=C\1N(C(C)=N/C1=C\C2=CC=C(OC)C=C2)C3=CC=C(CC(NCC4=CC=CC=C4)=O)C=C3

• Molecular Formula :

  C27H25N3O3

• Molecular Weight :

  439.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2559686-28-9