RTx-152

CAT: 0931-T209740-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T209740-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3035072-48-8
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Bioactivity
RTx-152 is an allosteric Pol?-pol inhibitor (IC50: 6.2 nM) that targets Pol? captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.
Smiles
O=C(OC=1C(=CC(=CC1C(F)(F)F)C(F)(F)F)N2C(=O)N(C)CC2)N(C3=CC=C(F)C=C3)C
Molecular Formula
C20H16F7N3O3
Molecular Weight
479.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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