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RTx-152

CAT: 0013-GTR19262384-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262384-01Size:10 mg
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Description
RTx-152 is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM) that targets Polθ captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.
CAS Number
3035072-48-8
Field of Research
Cell Biology, Molecular Biology
Smiles
O=C (OC=1C (=CC (=CC1C (F) (F) F) C (F) (F) F) N2C (=O) N (C) CC2) N (C3=CC=C (F) C=C3) C
Molecular Formula
C20H16F7N3O3
Molecular Weight
479.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

[2-(3-methyl-2-oxoimidazolidin-1-yl)-4,6-bis(trifluoromethyl)phenyl] N-(4-fluorophenyl)-N-methylcarbamate
CAS Number3035072-48-8
PubChem CID171391856
IUPAC Name[2-(3-methyl-2-oxoimidazolidin-1-yl)-4,6-bis(trifluoromethyl)phenyl] N-(4-fluorophenyl)-N-methylcarbamate
Molecular FormulaC20H16F7N3O3
Molecular Weight479.3
XLogP4.3
Topological Polar Surface Area53.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity725
SMILES
CN1CCN(C1=O)C2=CC(=CC(=C2OC(=O)N(C)C3=CC=C(C=C3)F)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C20H16F7N3O3/c1-28-7-8-30(17(28)31)15-10-11(19(22,23)24)9-14(20(25,26)27)16(15)33-18(32)29(2)13-5-3-12(21)4-6-13/h3-6,9-10H,7-8H2,1-2H3
InChIKey
OMLNQKKHSWHSNR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of [2-(3-methyl-2-oxoimidazolidin-1-yl)-4,6-bis(trifluoromethyl)phenyl] N-(4-fluorophenyl)-N-methylcarbamate
CAS: 3035072-48-8
CID: 171391856
Formula: C20H16F7N3O3
MW: 479.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.3
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass479.10798852
Monoisotopic Mass479.10798852
Topological Polar Surface Area53.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity725
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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