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PROTAC MLKL Degrader-2

CAT: 0931-T200218-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200218-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, MLK
Related Pathways
PROTAC, MAPK
Bioactivity
PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target protein ligand, E3 ligase ligand Thalidomide, and PROTAC Linker N-Methylpiperazine. The conjugate of the E3 ubiquitin ligase ligand and Linker is Thalidomide-N-Methylpiperazine. This compound exhibits antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.
Molecular Formula
C36H35N9O9S
Molecular Weight
769.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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