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PROTAC HDAC8 Degrader-2

CAT: 0931-T201111-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201111-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC HDAC8 Degrader-2 (compound 32a) acts as a degrader for HDAC8 with a DC50 of 8.9 nM and for HDAC6 with a DC50 of 14.3 nM. This compound is composed of a PROTAC target protein ligand HDAC8 ligand 1, an E3 ligase ligand thalidomide-4-OH, and PROTAC Linker 1,5-diaminopentane. The complex includes an E3 ubiquitin ligase ligand linked with the linker, specifically thalidomide-NH-C5-NH2.
Smiles
O=C(NC=1C=CC(=CC1)C2=NN(C(=O)CC2C)CCCCCN)N3CC=4C=NC=CC4C3
Molecular Formula
C39H44N10O8
Molecular Weight
780.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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GTR19277061-01PROTAC HDAC8 Degrader-4
HY-178803PROTAC BCL6 Degrader-2
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