Exatecan intermediate 10

• Description:

  Exatecan intermediate 10 is an intermediate in the synthesis of Exatecan (HY-13631) .Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 of 2[1].2 μM (0[1].975 μg/mL) for use in cancer research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Payload; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/exatecan-intermediate-10.html

• Purity:

  99.92

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O

• Molecular Formula:

  C26H24FN3O5

• Molecular Weight:

  477.48

• Precautions:

  H302, H315, H319, H335

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Camptothecins