Exatecan intermediate 10

• Description :

  Exatecan intermediate 10 is an intermediate in the synthesis of Exatecan (HY-13631) .Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 of 2[1].2 μM (0[1].975 μg/mL) for use in cancer research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Payload; Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/exatecan-intermediate-10.html

• Purity :

  99.92

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O

• Molecular Formula :

  C26H24FN3O5

• Molecular Weight :

  477.48

• Precautions :

  H302, H315, H319, H335

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Camptothecins