SDHD Antibody

CAT: 0223-56-248Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-248Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma.
NCBI Gene ID
6392
Swiss Prot
O14521
Accession Number
O14521
Host
Rabbit
Reactivity
Human
Immunogen
This SDHD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human SDHD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
17 kDa
Fragment
Rabbit Ig
Symbol
SDHD
NCBI Official Name
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Gill, A.J., et al. Hum. Pathol. 41 (6) :805-814 (2010)
Background Reference 03
Milosevic, D., et al. Clin. Biochem. 43 (7-8), 700-704 (2010) :
Background Reference 04
Hermsen, M.A., et al. Cell. Oncol. 32 (4) :275-283 (2010)
Other Product Names
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, CII-4, QPs3, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor subunit, SDHD, SDH4
Tested Applications
WB, IHC-P, IF, Flow
Physical Properties
Liquid

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