SDHD Antibody

• Background:

  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma.

• NCBI Gene ID:

  6392

• Swiss Prot:

  O14521

• Accession Number:

  O14521

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SDHD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human SDHD.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  17 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SDHD

• NCBI Official Name:

  Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Gill, A.J., et al. Hum. Pathol. 41 (6) :805-814 (2010)

• Background Reference 03:

  Milosevic, D., et al. Clin. Biochem. 43 (7-8), 700-704 (2010) :

• Background Reference 04:

  Hermsen, M.A., et al. Cell. Oncol. 32 (4) :275-283 (2010)

• Other Product Names:

  Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, CII-4, QPs3, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor subunit, SDHD, SDH4

• Tested Applications:

  WB, IHC-P, IF, Flow

• Physical Properties:

  Liquid