WAS Antibody

CAT: 0223-60-596Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-596Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
NCBI Gene ID
7454
Swiss Prot
P42768
Accession Number
P42768
Host
Rabbit
Reactivity
Human
Immunogen
This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human WAS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
WAS
NCBI Official Name
Wiskott-Aldrich syndrome protein
NCBI Organism
Homo sapiens
Background Reference 01
Burns, S.O., et al. Blood 115 (26) :5355-5365 (2010)
Background Reference 02
Taylor, M.D., et al. Sci Transl Med (37), 37RA44 (2010) :
Background Reference 03
Rajmohan, R., et al. FEMS Yeast Res. 9 (8) :1226-1235 (2009)
Background Reference 04
Dovas, A., et al. J. Cell. Sci. 122 (PT 21), 3873-3882 (2009) :
Other Product Names
Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2
Tested Applications
WB
Physical Properties
Liquid

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