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WAS Antibody

CAT: 223-64-160Size: 400 µLDry Ice: NoHazardous: No
400 µLSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients.
NCBI Gene ID
7454
Swiss Prot
P42768
Accession Number
P42768
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-144 amino acids from the Central region of human WAS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Symbol
WAS
NCBI Official Name
Wiskott-Aldrich syndrome protein
NCBI Organism
Homo sapiens
Background Reference 01
Rajmohan, R., et al. FEMS Yeast Res. 9 (8) :1226-1235 (2009)
Background Reference 02
Dovas, A., et al. J. Cell. Sci. 122 (PT 21), 3873-3882 (2009)
Background Reference 03
Cammer, M., et al. J. Biol. Chem. 284 (35) :23302-23311 (2009)
Background Reference 04
Zhang, J., et al. J. Biol. Chem. 284 (32) :21659-21669 (2009)
Other Product Names
Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2
Tested Applications
WB, IHC-P, Flow
Physical Properties
Liquid

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