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Anti-SDHD Antibody

CAT: 0519-A01261Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A01261Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH) . Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
Description
Boster Bio Anti-SDHD Antibody (Catalog # A01261) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
TRAP1, TRAP-1, SDH4, CII-4, CybS
Gene Name
SDHD
UniProt
O14521
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
At least four isoforms of SDHD are known to exist; this antibody will detect the two longest isoforms.
Immunogen
SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD. The immunogen is located within amino acids 30 - 80 of SDHD.
Clonality
Polyclonal
Applications
ELISA, WB, ICC, IF
Field of Research
Cancer, Cell Cycle
Purification
SDHD Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) . .
Molecular Weight
17043 MW
Shipping Conditions
Available
Storage Conditions
SDHD antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Succinate dehydrogenase complex, subunit D, integral membrane protein
Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Prediction Reactivity
Bovine, Sheep, Pig
Protein Name
Succinate dehydrogenase complex, subunit D, integral membrane protein

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