SDHB Antibody

CAT: 0223-26-268Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-26-268Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
6390
Swiss Prot
P21912
Accession Number
NP_002991
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SDHB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SDHB antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
31 kDa
Applications Notes
SDHB antibody can be used for detection of SDHB by ELISA at 1:62500. SDHB antibody can be used for detection of SDHB by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SDHB
NCBI Official Name
Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
NCBI Organism
Homo sapiens
Background Reference 01
Cascon, A., (2008) J. Med. Genet. 45 (4), 233-238.
Other Product Names
SDHB, IP, PGL4, SDH, SDH1, SDHIP, CWS2, SDH2
Tested Applications
ELISA, WB
Protein ID
115387094
Physical Properties
Liquid

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