SDHB Antibody

• Background :

  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

• NCBI Gene ID :

  6390

• Swiss Prot :

  P21912

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  HepG2

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 32kDa

• Fragment :

  IgG

• Symbol :

  SDHB

• Positive Control 2 :

  HeLa

• Positive Control 3 :

  U-87MG

• Positive Control 4 :

  Mouse brain

• Positive Control 5 :

  Mouse liver

• Positive Control 6 :

  Mouse kidney

• NCBI Official Name :

  Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  SDHB, IP, PGL4, SDH, SDH1, SDHIP, CWS2, SDH2

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid