SDHB Antibody

• Background:

  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

• NCBI Gene ID:

  6390

• Swiss Prot:

  P21912

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 32kDa

• Fragment:

  IgG

• Symbol:

  SDHB

• Positive Control 2:

  HeLa

• Positive Control 3:

  U-87MG

• Positive Control 4:

  Mouse brain

• Positive Control 5:

  Mouse liver

• Positive Control 6:

  Mouse kidney

• NCBI Official Name:

  Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SDHB, IP, PGL4, SDH, SDH1, SDHIP, CWS2, SDH2

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid