Products for Research Use Only
RegisterLogin

SDHB Antibody

CAT: 0223-60-810Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-60-810Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
NCBI Gene ID
6390
Swiss Prot
P21912
Accession Number
P21912
Host
Rabbit
Reactivity
Human
Immunogen
This SDHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SDHB
NCBI Official Name
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Cerecer-Gil, N.Y., et al. Clin. Cancer Res. 16 (16) :4148-4154 (2010)
Background Reference 04
Schimke, R.N., et al. Am. J. Med. Genet.152A (6), 1531-1535 (2010) :
Other Product Names
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip, SDHB, SDH, SDH1
Tested Applications
WB
Protein ID
20455488
Physical Properties
Liquid

Related Products

CatalogName
46-345PSDHB Peptide
18-730SDHA Antibody
6847-01mgSDHD Antibody
56-248SDHD Antibody
6847-01SDHD Antibody
60-990SDHA Antibody
6847-002mgSDHD Antibody
6847PSDHD Peptide
64-160WAS Antibody
60-596WAS Antibody

Alternative Products

CatalogName
70R-12822SDHB antibody

Popular Products