SDHB Antibody

• Background :

  Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

• NCBI Gene ID :

  6390

• Swiss Prot :

  P21912

• Accession Number :

  P21912

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This SDHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  32 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  SDHB

• NCBI Official Name :

  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 02 :

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03 :

  Cerecer-Gil, N.Y., et al. Clin. Cancer Res. 16 (16) :4148-4154 (2010)

• Background Reference 04 :

  Schimke, R.N., et al. Am. J. Med. Genet.152A (6), 1531-1535 (2010) :

• Other Product Names :

  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip, SDHB, SDH, SDH1

• Tested Applications :

  WB

• Protein ID :

  20455488

• Physical Properties :

  Liquid