SDHD Antibody

CAT: 0223-6847-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6847-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH) . Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
NCBI Gene ID
9392
Swiss Prot
O14521
Accession Number
NP_002993
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
SDHD Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Sheep: (100%), Pig: (80%)
Buffer
SDHD Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SDHD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms of SDHD are known to exist; this antibody will detect the two longest isoforms.
Symbol
SDHD
Positive Control 2
Cat. No. 17-207 - EL4 Cell Slide
NCBI Official Name
Succinate dehydrogenase complex, subunit D, integral membrane protein
NCBI Organism
Homo sapiens
Background Reference 01
Baysal BE, Ferrell RE, Willett-Brozick JE, et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000; 287:848-51.
Background Reference 02
Saraste M. Oxidative phosphorylation at the fin de siecle. Science 1999; 283:1488-93.
Background Reference 03
Knudson AG. Genetics of human cancer. Annu. Rev. Genet. 1986; 20:231-51.
Background Reference 04
Gimenez-Roqueplo AP, Favier J, Rustin P, et al. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of Complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am. J. Hum. Genet. 2001; 69:1186-97.
Other Product Names
SDHD Antibody: TRAP1, TRAP-1, SDH4, CII-4, CybS
Tested Applications
ELISA, WB, ICC, IF
Protein ID
4506865
Physical Properties
Liquid

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