Products for Research Use Only
RegisterLogin

AMN082 (free base)

CAT: 0804-HY-103565A-06Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-103565A-06Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2].
CAS Number
83027-13-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amn082-free-base.html
Purity
98.37
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C(C1=CC=CC=C1)(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C28H28N2
Molecular Weight
392.54
References & Citations
[1]Mitsukawa K, et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A. 2005;102 (51) :18712-18717.|[2]Wang CC, et al. Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal. Eur J Pharmacol. 2018;823:11-18.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Amn082

N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a member of benzenes, a diamine, a secondary amino compound and a diarylmethane. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).

CAS Number83027-13-8
PubChem CID1894361
IUPAC NameN,N'-dibenzhydrylethane-1,2-diamine
Molecular FormulaC28H28N2
Molecular Weight392.5
XLogP5.7
Topological Polar Surface Area24.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count9
Heavy Atom Count30
Formal Charge0
Complexity362
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4
InChI
InChI=1S/C28H28N2/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26/h1-20,27-30H,21-22H2
InChIKey
DTZDSNQYNPNCPK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amn082
CAS: 83027-13-8
CID: 1894361
Formula: C28H28N2
MW: 392.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.5
XLogP35.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count9
Exact Mass392.225248902
Monoisotopic Mass392.225248902
Topological Polar Surface Area24.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity362
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-103565-01AMN082
HY-103565R-01AMN082 (Standard)
HY-109118Masupirdine (free base)
HY-152852-01Mefatinib (free base)
HY-19651-01Zanapezil (free base)
HY-116031ATC0175 (free base)
HY-120421SW116 (free base)
HY-139806SRA880 (free base)
HY-100444-01SIS3 (free base)
HY-116565A-01Usmarapride (free base)

Alternative Products

CatalogName
BUP07262-01AMN082 free base
TB0954TMB free base
A8893-10Rucaparib (free base)
FX56092-01Xylazine - free base
T-8100-01Tryptamine, free base
XN175452-01Norharman - free base
MBS5779607Amidantel free base
533249ML355 free base
414310Neamine Free Base
596942Carnosine free base

Popular Products