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Hu7691 (free base)

CAT: 0804-HY-132302A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132302A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice[1].
CAS Number
2241232-43-7
UNSPSC
12352005
Target
Akt; PKA; PKC; Ribosomal S6 Kinase (RSK) ; ROCK; SGK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hu7691-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H]1CNCC[C@H]1C2=CC=C(F)C(F)=C2)C3=CC=C(C4=CC=NN4C)C=C3F
Molecular Formula
C22H21F3N4O
Molecular Weight
414.42
References & Citations
[1]Jinxin Che, et al. Discovery of N- ((3 S,4 S) -4- (3,4-Difluorophenyl) piperidin-3-yl) -2-fluoro-4- (1-methyl-1 H-pyrazol-5-yl) benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity. J Med Chem. 2021 Aug 26;64 (16) :12163-12180.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1; Akt2; Akt3; p70S6K; PKA; PKCη; ROCK1

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