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AS2863619 (free base)

CAT: 0804-HY-126675-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126675-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].
CAS Number
2241300-50-3
UNSPSC
12352005
Target
CDK; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/as2863619-free-base.html
Purity
99.87
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5
Molecular Formula
C16H12N8O
Molecular Weight
332.32
References & Citations
[1]Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4 (40) . pii: eaaw2707.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK19; CDK8; GSK-3α; GSK-3β; STAT5
Citation 01
JCI Insight. 2025 Jul 8;10 (15) :e182050.|Biomaterials. 2026 Feb:325:123574.|bioRxiv. 2025 Nov 20.|Cell Stem Cell. 2024 Jun 6;31 (6) :795-802.e6.|Elife. 2023 Dec 6:12:RP88874.|Patent. US20250230411A1.

Chemical Information

AS2863619 (free base)
CAS Number2241300-50-3
PubChem CID139600292
IUPAC Name4-[1-(2-methyl-3H-benzimidazol-5-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine
Molecular FormulaC16H12N8O
Molecular Weight332.32
XLogP1.2
Topological Polar Surface Area124
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity495
SMILES
CC1=NC2=C(N1)C=C(C=C2)N3C4=C(C=NC=C4)N=C3C5=NON=C5N
InChI
InChI=1S/C16H12N8O/c1-8-19-10-3-2-9(6-11(10)20-8)24-13-4-5-18-7-12(13)21-16(24)14-15(17)23-25-22-14/h2-7H,1H3,(H2,17,23)(H,19,20)
InChIKey
OORKHRHPVSWORX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AS2863619 (free base)
CAS: 2241300-50-3
CID: 139600292
Formula: C16H12N8O
MW: 332.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.32
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass332.11340704
Monoisotopic Mass332.11340704
Topological Polar Surface Area124 Ų
Heavy Atom Count25
Formal Charge0
Complexity495
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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