AS2863619 (free base)

AS2863619 (free base)

• CAS Number: 2241300-50-3
• UNSPSC Description: AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].
• Target Antigen: CDK; STAT
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;JAK/STAT Signaling;Stem Cell/Wnt
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/as2863619-free-base.html
• Purity: 99.87
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5
• Molecular Weight: 332.32
• References & Citations: [1]Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported