AFP464 (free base)

CAT: 0804-HY-16031Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-16031Size:1 Each
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Description
AFP464 free base (NSC710464 free base), is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.
CAS Number
[468719-52-0]
Product Name Alternative
NSC710464 (free base)
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AFP464.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=CC(C3=C(N)C(F)=C(C)C(F)=C3O2)=O)C=C1F)[C@@H](N)CCCCN
Molecular Formula
C22H23F3N4O3
Molecular Weight
448.44
References & Citations
[1]Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70 (17) :6837-48.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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