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Xaliproden (free base)

CAT: 0804-HY-119820Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119820Size:1 Each
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Description
Xaliproden free base is an orally active and selective 5-HT1A receptor agonist. Xaliproden free base shows analgesic effect against acute tonic nociceptive pain and has neuroprotective effects. Xaliproden free base has an acute inhibitory effect on paclitaxel -induced mechanical allodynia by inhibiting the excessive response of primary afferent neurons[1].
CAS Number
135354-02-8
Product Name Alternative
SR57746A (free base)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xaliproden-free-base.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC(C2=CCN(CC2)CCC3=CC=C4C=CC=CC4=C3)=CC=C1
Molecular Formula
C24H22F3N
Molecular Weight
381.43
References & Citations
[1]Andoh T, et al. Effects of xaliproden, a 5-HT₁A agonist, on mechanical allodynia caused by chemotherapeutic agents in mice. Eur J Pharmacol. 2013 Dec 5;721 (1-3) :231-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor

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