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KF24345 (free base)

CAT: 0804-HY-117569Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117569Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC50 values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice[1].
CAS Number
178750-21-5
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kf24345-free-base.html
Smiles
O=C(N(C1=C(C2=O)C=C(C=C1)C)C)N2C3CCN(CC3)C4=C5C=C(C(OCC)=CC5=NC(N6CCOCC6)=N4)OCC
Molecular Formula
C31H38N6O5
Molecular Weight
574.67
References & Citations
[1]Noji T, et al. KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-α production and leukopenia via endogenous adenosine in mice[J]. Journal of Pharmacology and Experimental Therapeutics, 2002, 300 (1) : 200-205.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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