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AMN082 (Standard)

CAT: 0804-HY-103565R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103565R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMN082 (Standard) is the analytical standard of AMN082. This product is intended for research and analytical applications. AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2].
CAS Number
97075-46-2
UNSPSC
12352005
Target
MGluR; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
[H]Cl.[H]Cl.C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C28H30Cl2N2
Molecular Weight
465.46
References & Citations
[1]Mitsukawa K, et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A. 2005;102 (51) :18712-18717.|[2]Wang CC, et al. Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal. Eur J Pharmacol. 2018;823:11-18.|[3]Jenda M, et al. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;57:166-175.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride

AMN082 dihydrochloride is a hydrochloride obtained by combining N,N'-bis(diphenylmethyl)ethane-1,2-diamine with two molar equivalent of hydrochloric acid. It has a role as a geroprotector, a metabotropic glutamate receptor agonist and a neuroprotective agent. It contains a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).

CAS Number97075-46-2
PubChem CID11698390
IUPAC NameN,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride
Molecular FormulaC28H30Cl2N2
Molecular Weight465.5
Topological Polar Surface Area24.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count2
Rotatable Bond Count9
Heavy Atom Count32
Formal Charge0
Complexity362
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
InChI
InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
InChIKey
YRQCDCNQANSUPB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
CAS: 97075-46-2
CID: 11698390
Formula: C28H30Cl2N2
MW: 465.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight465.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count2
Rotatable Bond Count9
Exact Mass464.1786044
Monoisotopic Mass464.1786044
Topological Polar Surface Area24.1 Ų
Heavy Atom Count32
Formal Charge0
Complexity362
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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