AV-412 free base

• Target:

  EGFR

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

• Bioactivity:

  AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR (T790M), EGFR (L858R), EGFR (L858R/T790M) and ErbB2) .

• Smiles:

  CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

• Molecular Formula:

  C27H28ClFN6O

• Molecular Weight:

  507

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  451492-95-8