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AV-412 (free base)

CAT: 0804-HY-10346A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10346A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
CAS Number
451492-95-8
Product Name Alternative
MP-412 free base
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AV-412-free-base.html
Purity
98.33
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C=C)NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1C#CC(C)(C)N(CC4)CCN4C
Molecular Formula
C27H28ClFN6O
Molecular Weight
507.00
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Suzuki T, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98 (12) :1977-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2
Citation 01
Science. 2017 Dec 1;358 (6367) :eaan4368.|Cancer Med. 2024 May;13 (10) :e7083.|Nature. 2025 Nov 26.|Proc Natl Acad Sci U S A. 2019 Feb 19;116 (8) :2996-3005. |Sci Data. 2024 Sep 19;11 (1) :1024.

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