SNIPER (ABL) -058

• Target :

  SNIPERs|||Others|||Bcr-Abl

• Related Pathways :

  Angiogenesis|||Tyrosine Kinase/Adaptors|||Others|||PROTAC|||Cytoskeletal Signaling

• Bioactivity :

  SNIPER (ABL) -058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 10 ?M[1].

• Smiles :

  C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(=O)N5CCN(CC6=CC=C(C(NC7=CC(NC=8N=C(C=CN8)C=9C=CC=NC9)=C(C)C=C7)=O)C=C6)CC5)=CC=C4)=CS3)[H]

• Molecular Formula :

  C62H75N11O9S

• Molecular Weight :

  1150.39

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2222354-61-0