SNIPER (ABL) -058

• Target:

  SNIPERs|||Others|||Bcr-Abl

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors|||Others|||PROTAC|||Cytoskeletal Signaling

• Bioactivity:

  SNIPER (ABL) -058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 10 ?M[1].

• Smiles:

  C ([C@@H] (NC ([C@@H] (NC) C) =O) C1CCCCC1) (=O) N2[C@@] (CCC2) (C3=NC (C (=O) C4=CC (OCCOCCOCCOCC (=O) N5CCN (CC6=CC=C (C (NC7=CC (NC=8N=C (C=CN8) C=9C=CC=NC9) =C (C) C=C7) =O) C=C6) CC5) =CC=C4) =CS3) [H]

• Molecular Formula:

  C62H75N11O9S

• Molecular Weight:

  1150.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2222354-61-0